Enzymatic electrochemical biosensor for glucose detection based on biomass-derived Fe3O4/C and PEDOT:PSS modification

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dc.authorid0000-0001-5807-633X
dc.contributor.authorKesici-Meco, Ece
dc.contributor.authorUnur-Yilmaz, Ece
dc.date.accessioned2026-02-08T15:14:58Z
dc.date.available2026-02-08T15:14:58Z
dc.date.issued2024
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractEnzyme-based electrochemical biosensors allow sensitive and selective detection of blood glucose levels and enable diabetes patients personalize their treatment plans. Biocompatible, low-toxic, abundant and electroactive iron oxide (Fe3O4) nanoparticles are widely used as biosensor electrode materials. Herein, Fe3O4/Carbon (Fe3O4/C) nanocomposite was obtained through hydrothermal carbonization and successive calcination of heteroatom-rich spirulina (Arthrospira platensis,SP) biomass on Fe3O4 nanoparticles. Functionality and electrical conductivity of the Fe3O4/C nanocomposite was further enriched by a conductive poly(3,4-ethylenedioxythiophene) polystyrenesulfonate coating (Fe3O4/C/PEDOT:PSS). Glucose oxidase (GOx) was physically immobilized on the electrodes and glucose was detected by means of electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) methods. The glucose detection limits for the Fe3O4/C/GOx electrode were calculated as 0.73 mM (CV) and 1.04 mM (EIS) in the linear concentration range of 5-15 mM. The glucose detection limits for the Fe3O4/C/PEDOT:PSS/GOx electrode were calculated as 0.03 mM (CV) and 0.13 mM (EIS) in the linear concentration range of 0.5-1.5 mM. The selectivity of the biosensor was tested in the presence of ascorbic acid. Sensitive, selective, low-cost, and biocompatible electrodes provide a valuable tool in the management of diabetes.
dc.description.sponsorshipBursa Technical University (TR)
dc.description.sponsorshipWe thank Prof. Dr. Mete YILMAZ for supplying commercial Spirulina.
dc.identifier.doi10.1007/s10854-024-13885-7
dc.identifier.issn0957-4522
dc.identifier.issn1573-482X
dc.identifier.issue33
dc.identifier.scopus2-s2.0-85209908319
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10854-024-13885-7
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5532
dc.identifier.volume35
dc.identifier.wosWOS:001362676200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Materials Science-Materials in Electronics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectHydrothermally Treated Biomass
dc.subjectNanoporous Carbons
dc.subjectPrussian Blue
dc.subjectThin-Film
dc.subjectOxidase
dc.subjectNanoparticles
dc.subjectComposite
dc.subjectSensors
dc.subjectPoly(3,4-Ethylenedioxythiophene)
dc.subjectImmobilization
dc.titleEnzymatic electrochemical biosensor for glucose detection based on biomass-derived Fe3O4/C and PEDOT:PSS modification
dc.typeArticle

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