Enzyme inhibitory, antioxidant, antimicrobial activities, and phenolic profiles of the methanol extract of Gelasia sericea an endemic species

Basit Öğe Kaydı
dc.contributor.authorAygul, Imdat
dc.contributor.authorAkmese, Osman
dc.contributor.authorSefali, Abdurrahman
dc.contributor.authorBaltaci, Cemalettin
dc.contributor.authorOz, Mehmet
dc.contributor.authorFidan, Muhammed Said
dc.date.accessioned2026-02-08T15:15:52Z
dc.date.available2026-02-08T15:15:52Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThis study aimed to investigate, for the first time, the phytochemical composition, antioxidant, antimicrobial, and enzyme inhibitory properties of the methanolic extract of Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N.Kilian. The extract demonstrated a moderate yield (6.55 g/100 g dry plant material) and was found to be rich in phenolic acids, particularly ferulic acid (17182.97 mu g g-1), followed by caffeic acid, protocatechuic acid, and p-coumaric acid. Antioxidant analyses revealed high total phenolic (388.86 mg GA eq./100 g), total flavonoid (74.03 mg QE eq./100 g), and total antioxidant capacity (503.33 mg AA eq./100 g). The extract exhibited remarkable ABTS radical scavenging activity (95.99%, IC50 = 37.59 mg ml-1) and considerable ferric-ion reducing power (974.78 mg FeSO4 eq./100 g). Antimicrobial assays indicated moderate inhibitory effects, with stronger activity against Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis) and the yeast Candida albicans, whereas Gram-negative bacteria were less susceptible. The extract's MIC values ranged between 0.20-3.25 mg ml-1, and MLC values between 0.41-6.50 mg ml-1, which were higher than those of standard antibiotics. Enzyme inhibition assays revealed moderate activity against carbonic anhydrase II (IC50 = 0.0136 mu g ml-1) and weak inhibition of cholinesterases and alpha-glucosidase, while alpha-amylase inhibition was relatively more pronounced (IC50 = 13350.00 mu g ml-1). Overall, these findings highlight G. sericea as a valuable natural source of phenolic acids and antioxidants, with promising potential for applications in functional foods, nutraceuticals, and phytopharmaceuticals. However, the relatively limited antimicrobial and enzyme inhibitory activities suggest the need for further studies on bioavailability, in vivo efficacy, and compound isolation to optimize its practical applications.
dc.identifier.doi10.15835/nbha53414819
dc.identifier.issn0255-965X
dc.identifier.issn1842-4309
dc.identifier.issue4
dc.identifier.urihttps://doi.org/10.15835/nbha53414819
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5980
dc.identifier.volume53
dc.identifier.wosWOS:001654109200022
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherUniv Agr Sci & Veterinary Med Cluj-Napoca
dc.relation.ispartofNotulae Botanicae Horti Agrobotanici Cluj-Napoca
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectantimicrobial activity
dc.subjectantioxidant activity
dc.subjectenzyme inhibition
dc.subjectGelasia sericea
dc.subjectmethanolic extract
dc.subjectphenolic compounds
dc.titleEnzyme inhibitory, antioxidant, antimicrobial activities, and phenolic profiles of the methanol extract of Gelasia sericea an endemic species
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu