Evaluating the Anticancer Potential of Green-Synthesized Silver/Silver Oxide and Copper/Copper Oxide Nanoparticles From Walnut Leaf Extract on Prostate Cancer Cells

Basit Öğe Kaydı
dc.authorid0000-0002-3589-2059
dc.contributor.authorAksel, Mehran
dc.contributor.authorOzen, Murat
dc.contributor.authorKaraagac, Dursun
dc.date.accessioned2026-02-08T15:14:51Z
dc.date.available2026-02-08T15:14:51Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractGreen synthesis is a method used to obtain metal/metal oxide nanoparticles from plant roots, stems, and leaves. In this study, Ag/Ag2O and Cu/CuO nanoparticles (NPs) were synthesized by utilizing the reducing, stabilizing and capping properties of the extract obtained from walnut (Juglans regia) leaves. The characteristic properties of the synthesized NPs were determined using UV-visible spectrophotometry (UV-vis), fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), energy dispersive X-ray diffraction (EDX), and powder X-ray diffraction (XRD). SEM images showed that Ag/Ag2O and Cu/CuO NPs were spherical in shape, with particle diameters ranging from 15 to 85 nm. EDX analysis confirmed the presence of silver, copper, and oxygen elements. The cytotoxic activity of the green-synthesized NPs was evaluated in vitro against PC3 prostate cancer cells and L929 fibroblast cells. Ag/Ag2O and Cu/CuO NPs exhibited significant cytotoxic activity against PC3 cells but showed comparatively lower cytotoxicity toward L929 cells. In contrast, the walnut leaf extract alone did not exhibit cytotoxic activity. According to the results, the synthesized nanoparticles demonstrated a cytotoxic effect on PC3 prostate cancer cells, and this effect was mediated through apoptosis.
dc.description.sponsorshipCentral Research Laboratory (MERLAB) at Bursa Technical University; Department of Chemistry at Bursa Technical University
dc.description.sponsorshipThe authors thank the Central Research Laboratory (MERLAB) at Bursa Technical University for the SEM-EDX and XRD measurements. The authors are also grateful to the Department of Chemistry at Bursa Technical University for the UV-vis and FTIR measurements.
dc.identifier.doi10.1002/slct.202504816
dc.identifier.issn2365-6549
dc.identifier.issue43
dc.identifier.scopus2-s2.0-105021873178
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202504816
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5471
dc.identifier.volume10
dc.identifier.wosWOS:001614717700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectAg/Ag2O NPs
dc.subjectCu/CuO NPs
dc.subjectGreen synthesis
dc.subjectPC3 prostate cell
dc.subjectProstate cancer
dc.titleEvaluating the Anticancer Potential of Green-Synthesized Silver/Silver Oxide and Copper/Copper Oxide Nanoparticles From Walnut Leaf Extract on Prostate Cancer Cells
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu