The preparation, characterization, and antibacterial activity evaluation of nanoliposomes incorporated with terebinth extract

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dc.contributor.authorYılmaz, Ali
dc.contributor.authorNizam, Nagihan
dc.contributor.authorMacit, Meltem
dc.contributor.authorDuman, Gulengul
dc.contributor.authorÇağal, Münevver
dc.date.accessioned2026-02-08T15:08:24Z
dc.date.available2026-02-08T15:08:24Z
dc.date.issued2023
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractNanoliposomes are drug release systems that increase bioavailability and are used for encapsulation of therapeutic active ingredients. Terebinth, which is a medicinal plant that grows in many parts of Türkiye, has antibacterial, antioxidant, and anti- inflammatory activity. The antibacterial activity of nanoliposomes incorporated with ethanol extract of terebinth leaves (TLE) was investigated to determine the effects of formulation. The nanoliposome formulation was prepared in two steps which were high pressure and high intensity homogenization techniques. Characterization parameters (zeta potential, particle size and distribution, polydispersity index, and encapsulation efficiency) were determined. After third cycle of microfluidization, the zeta potential charge of nanoliposome dispersion was measured -66.6 mV and 91.13 nm in size. The PDI was 0.231. Also, the nanoliposome encapsulation efficiency was calculated as 91.90%. The TLE was encapsulated with nanoliposomes and their antibacterial activity was examined by disk diffusion and minimum inhibition concentration tests against Escherichia coli ATTC 25922 and Staphylococcus aureus ATTC 25923. Nanoliposome encapsulated TLE (NLTLE) has antibacterial activity against S. aureus ATTC 25923. While NLTLE has less active substance, it displays the same antibacterial activity as TLE.
dc.identifier.doi10.38042/biotechstudies.1300663
dc.identifier.endpage48
dc.identifier.issn2687-3761
dc.identifier.issn2757-5233
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85190618626
dc.identifier.scopusqualityN/A
dc.identifier.startpage41
dc.identifier.trdizinid1222095
dc.identifier.urihttps://doi.org/10.38042/biotechstudies.1300663
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5011
dc.identifier.volume32
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofBiotech Studies
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260207
dc.subjectBiyoloji
dc.subjectMikrobiyoloji
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.titleThe preparation, characterization, and antibacterial activity evaluation of nanoliposomes incorporated with terebinth extract
dc.typeArticle

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