Studies of Novel Sulfapyridine Derivatives Containing Schiff Bases and Co(II), Ni(II) and Zn(II) Complexes: Synthesis, Experimental and Theoretical (DFT) Approach for Characterization and Biological Efficacy

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dc.authorid0000-0001-6314-3365en_US
dc.contributor.authorSahal, Hakan
dc.contributor.authorGur, Seher
dc.contributor.authorKaya, Mehmet
dc.contributor.authorTurkoglu, Semra
dc.contributor.authorFellah, Mehmet Ferdi
dc.date.accessioned2021-03-20T20:13:45Z
dc.date.available2021-03-20T20:13:45Z
dc.date.issued2017
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümüen_US
dc.description.abstractTwo new ligands were synthesized from sulfapyridine with 5-bromosalicylaldehyde (for (LH)-H-1) and 5-nitrosalicylaldehyde (for (LH)-H-2). Mononuclear complexes with metal ligand ratio 1:1 were prepared with Co(II), Ni(II) and Zn(II) salts. Their structures were elucidated on the basis of elemental analyses, IR, H-1-NMR and C-13-NMR spectra, electronic spectra, magnetic susceptibility measurements and thermogravimetric analyses (TGA). The synthesized compounds were tested for antimicrobial activity against bacterial and fungi in vitro by the minimum inhibitory concentration (MIC) method. All of the selected compounds showed strong antimicrobial activities against test microorganisms (32-256 mu g/mL). Furthermore, the antioxidant activities of the ligands and their complexes were determined by DPPH, metal chelating activity methods in vitro. The obtained IC50 value of the DPPH activity for the L-1-Ni complex (1.155 perpendicular to 0.054 mu M) and that of the metal chelating activity for the (LH)-H-2 ligand (% = 75 +/- 5.624) were higher than the values obtained for the other compounds. The computed stretching frequencies, UV spectral data and NMR spectra values were found to be in good agreement with experimental data.en_US
dc.identifier.endpage660en_US
dc.identifier.issn0253-5106
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage650en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12885/933
dc.identifier.volume39en_US
dc.identifier.wosWOS:000413747800021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorFellah, Mehmet Ferdi
dc.language.isoenen_US
dc.publisherChem Soc Pakistanen_US
dc.relation.ispartofJournal Of The Chemical Society Of Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectDPPHen_US
dc.subjectMetal Chelating Activityen_US
dc.subjectSulfa drugsen_US
dc.subjectDFTen_US
dc.subjectCoordination compoundsen_US
dc.titleStudies of Novel Sulfapyridine Derivatives Containing Schiff Bases and Co(II), Ni(II) and Zn(II) Complexes: Synthesis, Experimental and Theoretical (DFT) Approach for Characterization and Biological Efficacyen_US
dc.typeArticleen_US

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