Production and Characterization of Bio-based Sponges Reinforced with Hypericum perforatum oil (St. John?s Wort Oil) via Pickering Emulsions for Wound Healing Applications

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dc.authorid0000-0002-6523-206X
dc.contributor.authorParin, Fatma Nur
dc.contributor.authorDeveci, Sinan
dc.date.accessioned2026-02-12T21:05:11Z
dc.date.available2026-02-12T21:05:11Z
dc.date.issued2023
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractHypericum perforatum oil (HPO) was known as Saint John ' s wort oil which has antibacterial properties for medicinal applications. (topically to heal wounds). In this study, Pickering sponges containing HPO have been stabilized using beta-cyclodextrin (beta-CD) natural substance while Polyvinyl alcohol/sodium carboxymethyl cellulose (PVA/CMC) polymer matrices. The beta-CD/HPO inclusion complexes were added to the PVA/CMC sponges in various ratios (1 : 1, 1 : 4, and 1 : 8) and morphological, thermal and physical properties of sponges were investigated based on the ratios. SEM images revealed all Pickering PVA/CMC/HPO sponges has good porosity and PVA/CMC sponges containing (1 : 8 w/v) of beta-CD/HPO indicated the highest porosity. Furthermore, existence of HPO in the sponges were confirmed by FT-IR analysis. Similarly, thermal stability is increased as the beta-CD/HPO increased. Contact angle value rise from 12.7 degrees to 89.9 degrees as HPO concentration increased, and this value is the ideal hydrophobicity for the skin. Antibacterial efficiency showed good antibacterial activities of Pickering sponges containing the highest amount of HPO (1 : 8 w/v of beta-CD/HPO) against Gram (-) (Escherichia coli), and Gram (+) (Staphylococcus aureus, P. aeruginosa) bacteria with 13-17 mm zone inhibition diameter. All samples showed biocompatibility, and the material with the lowest amount of HPO (1 : 1 w/v of beta-CD/HPO) having the best biocompatibility. The increase in the HPO amount in Pickering sponges caused a decrease in mechanical properties. As a result, the resulting PVA/CMC/HPO Pickering sponges can be utilized in wound dressing applications owing to their imroved antibacterial activity results.
dc.description.sponsorshipTUEBITAK within the scope of the 2209-A project [1919B012100659]
dc.description.sponsorshipThe author gratefully acknowledge Dr. Ugur Parin for his kind help in the antibacterial measurements of the sponges ant Aydin Adnan Menderes University of Faculty of Veterinary Science, Microbiological Department. The author thanks to acknowledge Enver Baydir for his kind help in the contact angle measurements. The author thanks to Dr. Goekce Taner and Elife Kildali to perform biocompatibility test. This study was financially supported by TUEBITAK within the scope of the 2209-A project (Project number 1919B012100659).
dc.identifier.doi10.1002/slct.202203692
dc.identifier.issn2365-6549
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85147364522
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202203692
dc.identifier.urihttps://hdl.handle.net/20.500.12885/6840
dc.identifier.volume8
dc.identifier.wosWOS:000929659200011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260212
dc.subjectPVA
dc.subjectCMC blend
dc.subjectPickering emulsion
dc.subjectHypericum perforatum oil
dc.subjectwound healing
dc.subjectbio-based sponge
dc.titleProduction and Characterization of Bio-based Sponges Reinforced with Hypericum perforatum oil (St. John?s Wort Oil) via Pickering Emulsions for Wound Healing Applications
dc.typeArticle

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