Fabrication and Characterization of Calcium Alginate Beads with a Specially Designed Magnetic Pulse Encapsulator

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dc.authorid0000-0001-7611-4854
dc.authorid0000-0001-7530-7478
dc.authorid0000-0003-3375-8777
dc.authorid0000-0002-0086-8374
dc.contributor.authorDemircan, Seyda
dc.contributor.authorDemircan, Huseyin
dc.contributor.authorSarioglu, Kemal
dc.contributor.authorAtes, Ergun
dc.contributor.authorSeyhun, Nadide
dc.contributor.authorOral, Rasim Alper
dc.date.accessioned2026-02-08T15:14:50Z
dc.date.available2026-02-08T15:14:50Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractIn this study, a novel encapsulator system based on magnetic field principles was developed to produce gallic acid-loaded beads with an adjustable particle size and high production capacity. A dripping device was designed and optimized using the response surface methodology with a central composite design. Alginate concentration, nozzle diameter, frequency, distance, and flow rate were selected as independent variables. Bead properties, including encapsulation efficiency, production yield, loading capacity, particle diameter, aspect ratio, circularity, sphericity, polydispersity index, span, D10, D50, and D90, values were evaluated as response variables. In vitro release kinetics of the beads were investigated. Particle shape was mainly affected by all parameters except flow rate, while size distribution was predominantly governed by the alginate concentration, nozzle diameter, and frequency. Bead morphology strongly affected the release behavior, with smaller and more spherical beads showing faster release rates. The developed system successfully produced small-sized beads with high encapsulation efficiency (up to 60.7%). These findings demonstrate the potential of the proposed magnetic encapsulation system for the efficient encapsulation of gallic acid and other water-soluble phenolic compounds. Furthermore, its adaptability to multi- or interchangeable nozzle configurations makes it suitable for pilot- or industrial-scale production.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK) [221O549]; TUBITAK [1129B372201396]
dc.description.sponsorshipThis study was financially supported by The Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK), Project No: 221O549. The authors would like to thank Bursa Technical University and Erciyes University for their infrastructure support throughout this study. The authors also acknowledge the support of TUBITAK for the Process Analysis and Optimization Scientific Training Program (2237-A, Project No. 1129B372201396). Special thanks are extended to the coordinators and instructors of the program for their valuable contributions to the training and scientific development.
dc.identifier.doi10.1002/slct.202404272
dc.identifier.issn2365-6549
dc.identifier.issue25
dc.identifier.scopus2-s2.0-105009239074
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202404272
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5460
dc.identifier.volume10
dc.identifier.wosWOS:001516985000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectCalcium alginate beads
dc.subjectGallic acid encapsulation
dc.subjectMagnetic pulse encapsulator
dc.subjectResponse surface methodology
dc.titleFabrication and Characterization of Calcium Alginate Beads with a Specially Designed Magnetic Pulse Encapsulator
dc.typeArticle

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