Chemical Profiling and Biological Activities of Methanol Extracts and Essential Oils From Ferulago Platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties

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dc.contributor.authorAygul, İmdat
dc.contributor.authorÖz, Mehmet
dc.contributor.authorFidan, Muhammed Said
dc.contributor.authorBaltacı, Cemalettin
dc.contributor.authorAkmeşe, Osman
dc.contributor.authorSefali, Abdurrahman
dc.date.accessioned2026-02-08T15:11:13Z
dc.date.available2026-02-08T15:11:13Z
dc.date.issued2026
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThis study aimed to evaluate the phytochemical composition and biological activities of Ferulago platycarpa methanol extract (ME) and essential oil (EO). The EO was obtained via hydrodistillation and analyzed by GC-MS, revealing sesquiterpene hydrocarbons as the dominant class, with caryophyllene (65.8%) and ?-pinene (9.65%) as the major constituents. The methanol extract was subjected to LC-MS/MS analysis, which identified eleven phenolic compounds, with chlorogenic acid as the most abundant. The extract showed significantly higher total phenolic (1196.22±11.64 mg GAE/100g) and antioxidant (1870.00±17.69 mg QEE/100g) contents compared to the ME. In vitro enzyme inhibition assays demonstrated that the methanol extract exhibited potent inhibitory activity against carbonic anhydrase II (CA-II, IC<inf>SO</inf>= 0.023 pg/mL), acetylcholinesterase (AChE, IC<inf>SO</inf>= 110 pg/mL), and butyrylcholinesterase (BChE, IC<inf>50</inf>= 390 pg/mL). In contrast, the EO showed higher inhibition against ?-amylase (IC<inf>50</inf>= 5920±10.45 pg/mL) and BChE (IC<inf>50</inf>= 1.32±0.65 pg/mL), while its ?-glucosidase showed no inhibition. Antioxidant assays indicated superior activity for the methanol extract compared to the EO. Furthermore, antimicrobial testing revealed that the EO demonstrated broader and more effective antimicrobial action, exhibiting lower MIC and MBC values against several bacterial and fungal strains. Collectively, these results highlight F. platycarpa as a valuable source of bioactive compounds with promising applications in antidiabetic, neuroprotective, antioxidant, and antimicrobial therapies. © 2025, The Author(s).
dc.identifier.doi10.15376/biores.21.1.1110-1139
dc.identifier.endpage1139
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105026839141
dc.identifier.scopusqualityQ3
dc.identifier.startpage1110
dc.identifier.urihttps://doi.org/10.15376/biores.21.1.1110-1139
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5328
dc.identifier.volume21
dc.identifier.wosWOS:001671742800031
dc.identifier.wosqualityN/A
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNorth Carolina State University
dc.relation.ispartofBioResources
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzScopus_KA_20260207
dc.subjectAntioxidant and antimicrobial activities
dc.subjectEssential oil
dc.subjectFerulago platycarpa Boiss. & Balansa
dc.subjectGC-MS/FID
dc.titleChemical Profiling and Biological Activities of Methanol Extracts and Essential Oils From Ferulago Platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties
dc.typeArticle

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