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Öğe DBU-catalyzed synthesis of novel 2-amino-3-nitrile-4H-chromenes(Walter De Gruyter Gmbh, 2017) Koz, Gamze; Koz, ÖmerA simple method via the base-catalyzed Michael addition of nitroalkanes to 2-iminochromenes was developed, which leads to the production of highly functionalized 2-amino-3-nitrile-4H-chromenes in good yields.Öğe Enantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenes(Taylor & Francis Inc, 2016) Koz, Gamze; Koz, Ömer; Coskun, NecdetA series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu (II) catalytic system and moderate to good enantioselectivities (62-88%) and yields (66-96%) were obtained.Öğe GC-MS Analysis of n-Hexane Extract of Saponaria prostrata WILLD. subsp. anatolica HEDGE(2018) Koz, GamzeThe chemical constituents of n-hexane extract of S. prostrata WILLD. subsp. anatolica HEDGE which is an endemic species to Turkey was determined using GC-MS analysis. Twenty six components were identified with alpha-linolenic acid methyl ester and palmitic acid methyl ester as the most abundant components.Öğe GC-MS Analysis of N-Hexane Extracts of Turkish Ankyropetalum Species(2017) Koz, Gamze; Koz, ÖmerThe chemical constituents of crude n-hexane extracts of three Ankyropetalum species, Ankyropetalum gypsophiloides Fenzl, Ankyropetalum arsusianum Kotschy Ex Boiss. and Ankyropetalum reuteri Boiss. Et Hausskn. from Turkey was determined using GC-MS analysis. Thirty three components were identified with Palmitic Acid Methyl Ester and Oleic Acid Methyl Ester as the most abundant components.Öğe Regio- and diastereoselective synthesis of (E)-3-(2-aminochromen-4-yl)-6-aryl-substituted fulvenes(Verlag der Zeitschrift fur Naturforschung, 2016) Koz, Gamze; Şahin, O.; Coşkun, N.A practical base-catalyzed route was developed for the regio- and diastereoselective synthesis of (E)-3-aminochromene-6-aryl-disubstituted fulvenes in high yields up to 94% starting with the Michael addition of cyclopentadiene to 2-iminochromenes in the key step. © 2016, Verlag der Zeitschrift fur Naturforschung. All rights reserved.Öğe Synthesis and Molecular Docking Studies of Novel 5-Arylideneaminouracils(Maik Nauka/Interperiodica/Springer, 2019) Koz, GamzeA series of novel 5-arylideneaminouracils is synthesized from 5-aminouracil and substituted salicylaldehydes, and characterized by spectroscopic methods. DNA interactions of model molecules are explored using molecular docking simulations that reveal that these types of molecules can act as DNA groove binders.Öğe Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule(2018) Koz, GamzeAnovel uracil derived compound, (E)-5-((3-chloro-2-hydroxybenzylidene)amino) pyrimidine-2,4(1H,3H)- dione, was synthesized and characterized using spectroscopic techniques. The interaction of the molecule with DNA was explored using computational methods which revealed that the molecule could act as a groove binder. The physicochemical properties of the molecule such as frontier molecule orbitals and chemical reactivity parameters were also investigated.
