Yazar "Duman, Seyma" seçeneğine göre listele
Listeleniyor 1 - 12 / 12
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessing the effects of boron-doped biphasic calcium phosphate on the characteristics of chitosan-based composite foams(Springer, 2025) Acar, Nurcan; Mutlu, Busra; Akben, Hatice Kubra; Duman, SeymaIn this study, composite foams containing chitosan (CHI) and boron doped-biphasic calcium phosphate (BCP) were developed using freeze-drying method. The quantities of BCP incorporated into the CHI matrix were introduced into the foams at three different ratios: 25 wt%, 50 wt%, and 75 wt%. The objective of this study was to investigate the microstructure, swelling, mechanical, and biological properties of boron-doped BCP/CHI-based composites. Scanning electron microscopy (SEM) micrographs revealed that all of the composites exhibited open and interconnected pore morphologies. The FTIR spectra demonstrated that boron doping interacts with the hydroxyl and phosphate groups in the CHI/BCP composites, which is evidenced by changes in peak intensities. It was found that low amounts of boron positively affected the compressive strength and in vitro cytotoxicity of the composites. Following simulated body fluid treatment, the boron-doped BCP/CHI composites exhibited robust apatite layer formation. These results indicated that the composite foams with modified physical and mechanical characteristics show considerable promise for use as composite materials in biomedical applications, including bone scaffolds or wound dressings.Öğe Bionanocomposites in Bone Tissue Engineering(CRC Press, 2025) Terzioglu, Pinar; Mutlu, Büşra; Duman, Seyma[Abstract Not Available]Öğe Cryogenic milling-based keratin microparticle production from Anatolian goat fibers and their structural, chemical and thermal properties(Sage Publications Ltd, 2023) Duman, Seyma; Kucuk, MerveFibers procured from Anatolian goat (Capra aegagrus hircus) furs were converted into keratin microparticles by the cryogenic milling method. Single-stage mechanical milling with a 2.5 h optimal grinding time was sufficient enough to generate the desired high-quality microparticles. No chemical solvents were utilized during the production process of keratin microparticles. Structural, chemical and thermal properties of keratin microparticles were assessed using particle size analyzer, stereo microscope, Brunauer-Emmett-Teller (TM) surface analyzer, field emission scanning electron microscope, X-ray diffractometer, attenuated total reflection Fourier transform infrared spectroscopy, thermogravimetric analyzer and differential scanning calorimetry methods. According to the characterization results, microparticles with amorphous structure in micro size could be produced without any agglomeration during the milling process. Goat farming is usually for dairy products and their fibers have very limited use in the textile industry because of their flat structure. Therefore, the conversion of goat fibers into another product that can be used in other industrial areas is expected to contribute significantly to a sustainable economy.Öğe Curcumin-Loaded Akermanite/Chitosan/Carboxymethylcellulose Patches for Skin Wound Healing: Fabrication, Characterization, and In Vitro Cytocompatibility(Wiley-V C H Verlag Gmbh, 2025) Mutlu, Busra; Demirci, Fatma; Ercelik, Melis; Tekin, Cagla; Tunca, Berrin; Terzioglu, Pinar; Duman, SeymaIn this study, bioactive and biocompatible transdermal patches were fabricated through the lyophilization of a chitosan/carboxymethylcellulose/akermanite composite matrix. The influence of curcumin incorporation at 0.5%, 1%, and 2% on the physicochemical, morphological, and biological properties of the patches was systematically investigated. Scanning electron microscopy revealed an interconnected porous structure with pore sizes ranging from 29 to 57 mu m, facilitating cell infiltration and nutrient transport. Fourier transform infrared spectroscopy and energy-dispersive X-ray spectroscopy confirmed the successful integration of akermanite and curcumin, along with characteristic interactions within the polymeric network. In vitro release studies demonstrated a biphasic profile consisting of an initial burst followed by a sustained release phase, with the CCMAKCur0.5 sample achieving the highest cumulative release (94.28%). Antioxidant performance, evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, ranged from 21.55% (CCM) to 38.96% (CCMAKCur0.5), while higher curcumin concentrations reduced activity due to increased matrix densification. Simulated body fluid immersion confirmed apatite formation, particularly in CCMAKCur0.5 and CCMAKCur2, indicating enhanced bioactivity. Cytocompatibility studies with HUVECs showed no toxic effects, and scratch assays demonstrated that CCMAKCur0.5 most effectively promoted wound closure. Overall, the findings indicate that curcumin- and akermanite-loaded lyophilized patches represent promising candidates for transdermal therapeutic applications.Öğe In Vitro Behavior of Boron-Doped Baghdadite/Poly(vinylidene fluoride) Membrane Scaffolds Produced via Non-Solvent Induced Phase Separation(Wiley-V C H Verlag Gmbh, 2025) Mutlu, Busra; Demirci, Fatma; Erginer, Merve; Duman, SeymaThis study explores the potential of boron-doped baghdadite (BAG) powders incorporated into poly(vinylidene fluoride) (PVDF)-based membrane scaffolds for bone tissue engineering applications. The aim is to enhance the scaffolds' microstructure, surface wettability, thermal behavior, mechanical properties, and biological performance. Composite scaffolds are fabricated by integrating the powders into the PVDF matrix, yielding scaffolds with enhanced material characteristics and functionality. The incorporation of the powders significantly enhances the hydrophilicity of the scaffolds, as evidenced by a notable reduction in contact angle measurements. Mechanical analyses demonstrate that the addition of boron-doped BAG powders reduces the tensile strength and elongation at the break of PVDF scaffolds, attribute to increased pore size, reduced crystallinity, and structural heterogeneity, though the values remain within the range of human cancellous bone. Furthermore, in vitro bioactivity studies reveal the superior apatite-forming ability of the composite scaffolds, indicating their enhanced potential for biomineralization. The results of the cellular adhesion assays indicate an enhanced affinity and proliferation of cells on the membrane scaffolds, which is indicative of improved biocompatibility. In conclusion, the developed PVDF-based membrane scaffolds, reinforce with BAG powders, show promise as effective alternatives to traditional bone graft materials, offering scalable and versatile solutions for regenerative medicine.Öğe Incorporation of cerium oxide into hydroxyapatite/chitosan composite scaffolds for bone repair(Univ Novi Sad, Fac Technology, 2022) Mutlu, Busra; Caylak, Sena; Duman, SeymaThis study reports on the production of chitosan-based composite scaffolds reinforced with hydroxyapatite (HA) powders prepared with cerium oxide (CeO2) with various concentrations (10, 20, 30 wt.%). Besides, the effect of CeO2 additive on the microstructural, mechanical and bioactivity properties of the composite scaffolds was investigated. The CeO2 reinforced HA powders were synthesized having homogenous particle distribution via spray drying process. The synthesized powders and the produced scaffolds were examined using different characterization methods. From the results, it can be seen that the scaffolds were significantly affected by amount of CeO2 additive. An increase in the compressive strength is observed as the amount of CeO2 additive rises. Furthermore, the composite scaffolds possessed a high mineralization ability of apatite in simulated body fluid (SBF). These observations related to the composite scaffolds have considerable potency for application in bone tissue engineering.Öğe Influence of boron incorporated biphasic calcium phosphate on mechanical, thermal, and biological properties of poly(vinylidene fluoride) membrane scaffold(Wiley, 2024) Mutlu, Buesra; Demirci, Fatma; Duman, SeymaIn this paper, boron (B)-doped biphasic calcium phosphate (BCP)/poly(vinylidene fluoride) (PVDF) membrane scaffolds were developed by the combination of non-solvent induced phase separation and lyophilization processes. In addition, the effects of the synthesized B-incorporated BCP powders on the properties of the fabricated scaffolds were investigated. The physicochemical and morphological properties of the scaffolds were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy. The physical properties were evaluated by surface wettability and swelling measurements, whereas the mechanical properties were investigated by tensile strength measurements. The thermal behavior was determined by differential scanning calorimetry, the beta-crystallization ratio was calculated by FTIR, and the beta-phase structure was characterized by X-ray diffraction. The bioactivity was evaluated in the simulated body fluid, and the cytotoxicity of the scaffolds was also investigated by performing in vitro cell culture experiments. The results showed that the incorporation of B into the PVDF matrix improved the hydrophilicity while reducing the degree of swelling of the scaffolds. Tensile strength was slightly reduced by the powder content, but yet the strength of all scaffolds was mechanically compatible with native bone. Increasing the B content up to 0.5 and 1 wt.% was improved the thermal properties, the beta-crystalline phase fraction, and thus the piezoelectricity. Furthermore, B-doped BCP/PVDF-based scaffolds significantly promoted bioactivity, cell viability, and proliferation without cytotoxicity, compared to the PVDF scaffold, depending on the B content. In conclusion, our results indicate that the PVDF-based composites in the form of membrane scaffolds that support bone growth have the potential to be highly sought-after candidates in the field of biomedical applications.Öğe Investigating the impact of coagulation bath temperature on the properties of biphasic calcium phosphate/poly(vinylidene fluoride)-based membrane scaffold via immersion precipitation(Wiley, 2025) Mutlu, Buesra; Demirci, Fatma; Duman, SeymaIn this study, composite membrane scaffolds comprising poly(vinylidene fluoride) (PVDF) and boron-containing biphasic calcium phosphate (BCP) are developed using a non-solvent-induced phase separation technique at coagulation bath temperatures of -5, 0, 10, and 20 degrees C. The morphology, pore size and tensile strength of the scaffolds are primarily influenced by the bath temperature. Moreover, raising the bath temperature enhances the thermal properties and beta-crystalline phase fraction. Results demonstrate that changes in the temperature increase the surface hydrophilicity and reduce the degree of swelling. According to the in vitro bioactivity analysis, apatite growth is affected by the interactive relation between the surface of the samples and the simulated body fluid (SBF) medium, in addition to the superior bioactivity of the scaffolds. In vitro cytotoxicity assay results confirm the extensive spreading of L-929 cells on the sample surfaces, indicating the high biocompatibility of the scaffolds. Based on these favorable properties, the novel composite membranes produced, particularly at 20 degrees C coagulation bath temperature, may contribute to applications in bone tissue engineering. Fabrication of the BCP/PVDF-based membrane scaffold via immersion precipitation. imageÖğe PLA-Based 3D Porous Scaffolds with Bioceramics for Load-Bearing Bone Substitutes(Springer Nature, 2025) Ozer, Hayrunnisa; Mutlu, Büşra; Demirci, Fatma; Duman, SeymaThree-dimensional (3D) printing technology, which has been widely adopted in the field of regenerative medicine, represents a high-speed manufacturing process for biomaterials. Three-dimensional printing technology enables the precise fabrication of biomaterial scaffolds, thereby facilitating the creation of intricate structures that are tailored to the specific characteristics of the defect site. In this study, three-dimensional printing was employed to prepare composite scaffolds comprising poly (lactic acid) and monticellite. The composite scaffolds were optimized through material characterization, mechanical testing, density measurements, and in vitro swelling assessments. The results demonstrated that the Poly (lactic acid)/monticellite composites proposed in this study were highly printable, exhibiting tunable mechanical strength and density in conjunction with the monticellite component. Additionally, the in vitro swelling properties were demonstrated to be superior to those of the neat poly (lactic acid) scaffold. This composite scaffolding of poly (lactic acid) and monticellite represents a promising strategy for load-bearing bone substitutes. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.Öğe Polylactic acid/akermanite biocomposite films for food packaging applications(Springer, 2024) Yilmaz Dogan, Hazal; Terzioglu, Pinar; Duman, SeymaThis study investigated the incorporation of akermanite into a polylactic acid (PLA) matrix using the solution casting method, with akermanite ratios ranging from 0.05% to 2% w/w. To facilitate even distribution of akermanite, 5 wt% triacetin was used as a plasticizer. The resultant PLA/akermanite composite films were evaluated and compared against neat PLA and plasticized PLA films in terms of color, optical, physical, mechanical, thermal and structural properties. Fourier-transform infrared spectroscopy (FT-IR) revealed structural formations attributed to the added plasticizers and akermanite in the PLA matrix. The films containing akermanite showed reduced transparency compared to neat PLA. Differential Scanning Calorimetry (DSC) results indicated an enhancement in crystallinity with the addition of akermanite to the PLA matrix, which suggests improved thermal properties. Mechanical testing showed that the inclusion of triacetin decreased the tensile strength of the PLA films from 31.01 MPa to 29.19 MPa, while the Young's modulus increased from 1.23 GPa to 1.33 GPa. The elongation at break also improved significantly, rising from 5.60% to 8.26%. These changes indicate an overall enhancement in the ductility and stiffness of the films. Additionally, the water solubility and moisture content of the composite films decreased, whereas their water absorption increased compared to neat PLA. These results suggest that the PLA/akermanite composites, with altered physical and mechanical properties, have significant potential for use as biocomposite materials in food packaging applications, offering a sustainable alternative with enhanced performance characteristics.Öğe Production and characterization of keratin microparticles obtained from wool fibers by cryogenic milling method(Taylor & Francis Inc, 2022) Duman, Seyma; Kucuk, MerveIn this study, keratin particles were obtained from wool fibers by the cryogenic milling method without utilizing any chemical solvent. The optimal milling period and low energy expenditures are the predominant advantages of the proposed method as the first attempt to incorporate cryogenic milling into the process of keratin production from a wool resource. The configuration, size distribution, surface area, crystallinity, chemical composition, and thermal properties of keratin particles were assessed by a particle size analyzer, stereo microscope, Brunauer-Emmett-Teller (TM) surface analyzer, scanning electron microscope, x-ray diffractometer, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analyzer measurements. The characterization results indicate no alteration in the structural and chemical properties of keratin microparticles after cryogenic milling. The procurement of waste fibers from wool, one of the main raw materials of the textile industry, and processing them into keratin particles by an environment-friendly and innovative method can be considered the pioneering aspects of this study.Öğe Production and characterization of PLA based graphene, black carrot waste and huntite-hydromagnetite reinforced biocomposites(Gumushane University, 2025) Sönmez, Ayşenur; Duman, Seyma; Fidan, Muhammed SaidIn this study, biocomposite materials were produced by incorporating black carrot (KH), as a reinforcement material, graphene nanoplatelets (GNP) as additives, and huntite-hydromagnesite (HH) as mineral additives into a polylactic acid (PLA) matrix. A comprehensive investigation was conducted on the morphological, physical, mechanical, thermal, and flame retardant properties of the resulting biocomposites. The fabrication of the biocomposites was carried out through the implementation of a twin-screw extrusion method, subsequently followed by a process of hot press molding. Structural and morphological analysis were performed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) for characterization of the samples. Mechanical properties were evaluated by tensile, flexural, and impact strength tests. Thermal behavior was evaluated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and bending temperature under load (HDT) tests. The flame retardant performance of the samples was measured using the UL-94 V combustion test. The experimental findings revealed that the incorporation of KH and HH enhanced the degree of crystallization in all variations of PLA biocomposites. The incorporation of HH enhanced the degradation temperature of the matrix, concurrently augmenting its thermal atability and residual amount. In the PLA/GNP/KH biocomposite, the addition of KH led to a slight decrease in thermal strength, but it also slowed down the rate of mass loss and increased the residue rate. In the PLA/GNP/KH biocomposite, the addition of HH increased the thermal deformation temperature to 55.5 ºC, representing an improvement of 2.97% compared to pure PLA. The finding of this study indicate that the incorporation of KH and HH additives led to a substantial enhancement in the thermal performance of PLA-based biocomposites. © 2025, Gumushane University. All rights reserved.
