Yazar "Cinar, Aycan Yigit" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • Küçük Resim Yok
    Öğe
    Evaluation of microbiota-induced changes in biochemical, sensory properties and volatile profile of kombucha produced by reformed microbial community
    (Elsevier, 2024) Kilmanoglu, Hilal; Cinar, Aycan Yigit; Durak, Muhammed Zeki
    Kombucha is a traditional beverage produced by a living culture known as SCOBY or symbiotic culture of bacteria and yeast. Culture-dependent production is essential for stable kombucha fermentation. The aim of this study was to design a microbial community and to determine the effect of that community on the flavor and chemical properties of kombucha. The fermentations were carried out using combinations of selected species including Pichia kudriavzevii, Brettanomyces bruxellensis, Dekkera bruxellensis, Komagataeibacter saccharivorans, Komagataeibacter xylinus, and Acetobacter papayae, which were previously isolated from kombucha. The effects of monocultures and cocultures on fermentation were investigated. The highest acetic acid producer was A. papayae, which has strong antioxidant properties. In the monoculture and coculture fermentations, aldehydes, acids, and esters were generally observed at the end of fermentation. This study confirms that microbiota reconstruction is a viable approach for achieving the production of kombucha with increased bioactive constituents and consumer acceptance.
  • Küçük Resim Yok
    Öğe
    Facile fabrication of Ag decorated MnFeO3 catalyst: Comparative analysis of visible light driven antibiotic reduction and antibacterial performance
    (Academic Press Ltd- Elsevier Science Ltd, 2024) Karadirek, Seyda; Tuna, Ozlem; Simsek, Esra Bilgin; Altuntas, Seda; Cinar, Aycan Yigit
    Photocatalysis is an effective method with the potential to eliminate pharmaceutical compounds from water sources. Manganese ferrite (MnFeO3), a type of multiferroic perovskite catalyst, has attracted significant attention due to its small band gap, however its application was limited due to its high recombination rate and low quantum efficiency. It was therefore aimed to improve the properties of MnFeO3 by doping silver (Ag)-particles. In this study, Ag-MnFeO3 photocatalysts with different Ag content (1-3 mmol%) were synthesized by performing a facile hydrothermal method. The as-prepared samples were characterized using x-ray diffraction (XRD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS), transmission electron microscopy (TEM), x-ray photoelectron spectroscopy (XPS), ultraviolet-visible spectroscopy (DRS), photoluminescence spectroscopy (PL), electrochemical impedance spectroscopy (EIS) and Brunauer-Emmett-Teller (BET) method, showing successful addition of Ag-particles with the MnFeO3 structure. Then, the as-synthesized materials were investigated as: (i) photocatalysts for degradation tetracycline (TC) antibiotic and (ii) antibacterial agents for bacteria. The Ag-MnFeO3 catalyst demonstrated superior catalytic performance (95.7%), which was 1.6 times higher than that of pristine MnFeO3 (59.7%). The positive effect was ascribed to oxygen vacancies, enhanced light absorption ability, and lower recombination rate. The Ag-MnFeO3 catalyst also showed satisfactory removal performances in real water matrices. Furthermore, radical trapping tests depicted that the superoxide radicals played a dominant role in the photodegradation system. In addition, Box-Behnken design (BBD) was performed to determine the optimum conditions, which were determined as catalyst dosage of 0.45 g/L, initial TC concentration of 5.10 mg/L, and initial solution pH value of 3.69. In terms of antibacterial tests, the incorporation of Ag into the MnFeO3 structure greatly increased the antimicrobial resistance against bacteria. Our findings disclose that the incorporation of Ag into the MnFeO3 structure can be regarded as a feasible and promising approach to improve both photocatalytic degradation and antibacterial performances.
  • Küçük Resim Yok
    Öğe
    Kombucha as alternative microbial consortium for sourdough fermentation: Bread characterization and investigation of shelf life
    (Elsevier, 2024) Kilmanoglu, Hilal; Akbas, Meryem; Cinar, Aycan Yigit; Durak, Muhammed Zeki
    Kombucha is traditionally a functional beverage fermented by SCOBY (symbiotic culture of bacteria and yeasts) of sweet black tea. Kombucha has attracted consumers' attention recently thanks to its health benefits. The main objective of this study is to use kombucha microbiota as an alternative to baker's yeast to produce sourdough bread. Sourdough breads prepared with different amounts of kombucha and traditional sourdough bread were compared in terms of physical, chemical, microbiological, textural and sensory characteristics. A decrease in pH and an increase in total acidity occurred at the end of kombucha sourdough fermentations. The hardness and moisture content of lyophilized kombucha sourdough breads decreased compared to lyophilized sourdough breads, and accordingly, their specific volumes increased. The lyophilization process increased the overall acceptability of kombucha breads by 9%-13%. Adding kombucha to bread indicated a positive effect on preventing mold and the shelf life. Consequently, kombucha as a driver in sourdough fermentation can be an alternative to bring novel texture and flavor to the bakery industry.
  • Küçük Resim Yok
    Öğe
    Microbiological Control a Prerequisite for Sustainable Food Safety: a Case Study in a Dairy Dessert Facility
    (Inst Tecnologia Parana, 2024) Onbasi, Elif; Cinar, Aycan Yigit
    Dairy desserts have become a commercial product which produced in the industry and consumption is increasing worldwide. Ensuring food safety is becoming increasingly significant in dairy dessert which is microbiologically risky product. The combination of microbiological monitoring of both food products and the production environment is critical to provide food quality and safety. Environmental Monitoring Program (EMP) is a monitoring program which allows to evaluate effectiveness of general hygiene-sanitation operations and control programs to prevent possible microbial contamination of food. The aim of this study is to provide practical recommendations and strategies to build efficient EMP in the dairy desserts and food industry. During the implementation of the EMP (October 2019-March 2020), a total of 852 samples; dairy dessert (keskul) (n = 144), raw and auxiliary materials (n = 78), air (n = 96), water (n = 24), personnel (n = 144) and production surfaces (n = 366) microbiological conditions were examined within the parameters of Total Mesophilic Aerobic Bacteria (TMAB), coliform, Escherichia coli, Staphylococcus aureus and yeast-mold. The microbiological results of keskul before vs after the implementation of EMP was 3.81 vs. 2.55 log cfu/g for TMAB, 2.60 vs. 0.90 log cfu/g for coliforms, 0.58 vs. 0 log cfu/g for E. coli, 0 for S. aureus, 2.33 vs. 1.01 log cfu/g for yeast-mold and negative for Salmonella, respectively. Our study demonstrates that effective EMP plays a significant and crucial role in controlling microbiological hazards of final product.
  • Küçük Resim Yok
    Öğe
    Molecularly Imprinted Nanoparticle-Embedded Electrospun Mat as an Antibacterial Wound Dressing
    (Wiley, 2025) Cerci, Azize; Akgun, Oguzhan; Karaca, Esra; Bakhshpour-Yucel, Monireh; Ari, Ferda; Cinar, Aycan Yigit; Osman, Bilgen
    Molecularly imprinted polymer (MIP) nanoparticles offer a promising controlled drug delivery platform. In this study, amoxicillin (AMOX)-imprinted polymer nanoparticles (similar to 60 nm) were synthesized via emulsion polymerization and incorporated into polyvinyl alcohol (PVA)/sodium alginate (SA) [PVS] electrospun nanofibers to develop a novel wound dressing. The nanoparticle-embedded PVS nanofibers (PVS-AMOX-MIP) demonstrated a sustained cumulative drug release of 43.6% over 2 days, governed by non-Fickian transport per the Korsmeyer-Peppas kinetic model. The nanofibers exhibited favorable physical properties, including a high specific surface area (39.66 m(2)/g), optimal porosity (78.8%), and a water vapor transmission rate (1053.4 +/- 5.9 g/m(2)/day), ideal for wound healing. Antibacterial activity studies showed significant inhibition against Staphylococcus aureus and Escherichia coli, while biocompatibility assays confirmed the mat's noncytotoxic nature and ability to promote cell proliferation. Furthermore, angiogenesis studies revealed enhanced vascularization, which is critical for tissue regeneration. The developed strategy offers a unique approach for advanced wound care and controlled drug delivery applications by combining MIP nanoparticles' molecular recognition capability with the structural advantages of electrospun nanofibers.
  • Küçük Resim Yok
    Öğe
    Preparation, Characterization, and Antimicrobial Activities of Ceragenins Incorporated Into Polyvinyl Alcohol/Gelatin/Sodium Alginate-Based Hydrogels for Treatment of Burn Wounds
    (Wiley, 2025) Aljayyousi, Nawal; Irmak, Emel Tamahkar; Ozer, Elif Tumay; Cinar, Aycan Yigit; Guzel, Cagla Bozkurt; Savage, Paul B.; Osman, Bilgen
    Ceragenins are synthetic molecules that mimic antimicrobial peptides (AMPs) in the human immune system. They feature a bile acid-based structure with appended positively charged groups that disrupt bacterial cell membranes, leading to microbial cell death or inactivation. In this study, ceragenin CSA-44 was incorporated into a polyvinyl alcohol (PVA)/gelatin (G)/sodium alginate (SA)-based hydrogel (PGA-CSA). The hydrogel was cross-linked with glutaraldehyde (GA) for 20 min using a 0.125% GA (v/v) solution. The optimized volume ratios of the polymer solutions in the hydrogel were determined to be 2:1:3 (PVA:SA:G). PGA-CSA and PGA hydrogels were characterized using scanning electron microscopy (SEM), mercury porosimetry, and Fourier transform infrared spectroscopy (FTIR). The maximum swelling ratio of PGA-CSA was 780.48% +/- 14.80%, and the WVTR value was 905.4 +/- 35.4 g/m2/d. Drug release studies showed a cumulative CSA-44 release of 29.07% over 7 days. The antibacterial activity of the hydrogel was tested against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 19151, Staphylococcus aureus ATCC 29213, and MRSA. The tested bacteria were inhibited within 2, 2.5, 3, and 3.5 h, respectively. The developed PGA-CSA hydrogel demonstrated outstanding potential and unique characteristics as an antibacterial dressing for burn wounds.