Scale-up rules and reactor accessories

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dc.contributor.authorAslan, Emek
dc.contributor.authorDemirden, S. Furkan
dc.contributor.authorKimiz-Gebologlu, Ilgin
dc.contributor.authorSargın, Sait
dc.contributor.authorÖncel, Suphi Şurişvan
dc.date.accessioned2026-02-08T15:11:07Z
dc.date.available2026-02-08T15:11:07Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThe scale-up has critical importance for the development of bioprocess from bench, pilot to industrial scales to fulfill the path of the laboratory to market. Different strategies are employed to sustain bioprocess yield and productivity in larger volumes. While these strategies are primarily based on geometric aspects of bioreactors, vital parameters such as agitation or aeration for the requirements of living systems are also essential. Therefore the scale-up must take into account as a whole not only classical parameters such as power input and tip speed but also the effects of environmental parameters including physiology. These features are specific to each production and related to the complex response of living systems to rapid changes in environmental conditions under heterogeneous growing conditions, which mostly depend on rheology. While successful scale-up is crucial, in terms of rapid time-to-market, it is also important for transferring the process between various production facilities where the type, size, or design of the bioreactor changes. This chapter aims to focus on the theory of scale-up, comprising its definition and basics, without underestimating the engineering background and novel perspectives highlighting bioreactors. © 2025 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/B978-0-443-31476-6.00012-9
dc.identifier.endpage334
dc.identifier.isbn9780443314773
dc.identifier.isbn9780443314766
dc.identifier.scopus2-s2.0-105019730200
dc.identifier.scopusqualityN/A
dc.identifier.startpage309
dc.identifier.urihttps://doi.org/10.1016/B978-0-443-31476-6.00012-9
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5254
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_KA_20260207
dc.subjectBioreactor engineering
dc.subjectBioreactors
dc.subjectIndustrial production
dc.subjectScale-up
dc.subjectTraditional and intensified bioprocess
dc.titleScale-up rules and reactor accessories
dc.typeBook Chapter

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