Comparing the effectiveness of different vaccination regimens using Sinovac and BNT162b2 vaccines among hospitalised patients: A single-centre hospital-based retrospective cohort study

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dc.contributor.authorTuran, Atakan
dc.contributor.authorÖğüt, Hamdi
dc.contributor.authorVarol, Aylin Ayyıldız
dc.contributor.authorKoca, Nizameddin
dc.contributor.authorBozkurt, Hayri
dc.date.accessioned2026-02-08T15:08:14Z
dc.date.available2026-02-08T15:08:14Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractObjectives: This study aimed to assess the effectiveness of different vaccination regimens using two distinct SARS-CoV-2 vaccines against mortality risk and the need for intensive care unit (ICU) admission among hospitalised patients. Methods: The single-centre hospital-based retrospective cohort study was performed with adult COVID-19 patients in a tertiary-level hospital between March 2020 and September 2022. The associations between patients’ demographics and clinical features, vaccine status and regimens, in-hospital mortality, and need for ICU admission were evaluated using multivariable regression analyses. Results: During the study period, 2,373 patients were included. Mortality among unvaccinated patients was 85.0%, which was significantly lower in vaccinated groups (P<0.001), particularly with BNT162b2 than with Sinovac. Vaccination reduced mortality and ICU admission rates, with higher efficacy observed with increased vaccine doses and BNT162b2 regimens. Multivariable analyses confirmed age as a significant determinant and various vaccination schedules showed consistent reductions in mortality and ICU admissions. Conclusions: A two-dose initial plus one or more-dose booster BNT162b2 regimen effectively reduced mortality risks and ICU admission.
dc.identifier.doi10.18621/eurj.1632009
dc.identifier.endpage1175
dc.identifier.issn2149-3189
dc.identifier.issue6
dc.identifier.startpage1167
dc.identifier.trdizinid1356946
dc.identifier.urihttps://doi.org/10.18621/eurj.1632009
dc.identifier.urihttps://hdl.handle.net/20.500.12885/4858
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofThe European Research Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260207
dc.subjectCOVID-19
dc.subjectmortality
dc.subjectintensive care unit
dc.subjectvaccine
dc.titleComparing the effectiveness of different vaccination regimens using Sinovac and BNT162b2 vaccines among hospitalised patients: A single-centre hospital-based retrospective cohort study
dc.typeArticle

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