Advanced electrospun biomaterials for skin tissue engineering

Abstract

Autografts, allografts or xenografts can be applied for treating damaged skin tissue, but these methods have certain disadvantages such as additional damage to donor regions, increased infection risk, and risk of disease transmission. On the other hand, tissue engineered skin substitutes provide more advantageous properties including large sources and good bioactivity. Tissue engineering is an interdisciplinary field of science that aims to develop tissue-engineered substitutes or tissue scaffolds in order to replace, repair, maintain, and regenerate the tissue functions. For producing functional tissue scaffolds for use in tissue engineering, different fabrication methods have been used by scientists. One such technique is electrospinning, which has been recognized as a promising method for creating microstructures that closely resemble the extracellular matrix of skin tissue. In this review article, the aim was first to provide information about skin tissue-related problems, current treatment methods, electrospinning method and its working principle, and to review the recent literature on the applications of electrospinning for use in skin tissue engineering.