Effect of Copper Oxide Nanoparticles on Prostate Cancer PC3 Cells

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dc.contributor.authorAksel, Mehran
dc.contributor.authorKaraağaç, Dursun
dc.contributor.authorKaya, Refik Tolga
dc.contributor.authorAğırakar, Fatih
dc.contributor.authorKaya, Muhammed Buğra
dc.contributor.authorKızılcık, Pınar
dc.contributor.authorKuru, Alperen
dc.date.accessioned2026-02-08T15:08:18Z
dc.date.available2026-02-08T15:08:18Z
dc.date.issued2023
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractCopper oxide (CuO NPs) nanoparticles were synthesized by green synthesis and characterized by UV-Vis spectroscopy, FT-IR spectroscopy, SEM and EDX analysis. The shape of the CuO nanoparticles obtained is approximately spherical and their particle sizes range from 40 to 85 nm. According to the experimental results, two peaks at 305 and 318 nm in the 270-400 nm range in the UV-Vis absorption spectrum and one peak at 536 cm-1 in the FT-IR spectrum confirm the presence of copper oxide nanoparticles. In addition, the presence of biomolecules in aesculus hippocastanum(horse chestnut) extract on the surface of the copper oxide nanoparticles synthesized by green synthesis was determined by the peaks seen in the range of 3300 cm-1 - 1000 cm-1 in the FTIR spectrum. The images, shape and size of the copper oxide nanoparticles were determined by SEM, and the weight percent of the elements were determined by EDX. PC3 prostate cell lines were used in the study. After measuring the cytotoxic effect of the agents used in the study on prostate cancer cells, the apoptotic effect of this effect was determined by Hoechst/propidium iodide (HOPI) staining. Graphpad prism program was used to compare all parameters between groups, and \"one-way analysis of variance\" (one-way ANOVA) method and dunnet's test were applied to test whether there was any difference between at least two groups. It has been determined that the drug obtained from copper oxide nanoparticles has a cytotoxic effect on PC3 prostate cancer cells and this effect occurs through the apoptosis pathway.
dc.identifier.doi10.29132/ijpas.1304265
dc.identifier.endpage351
dc.identifier.issn2149-0910
dc.identifier.issue2
dc.identifier.startpage344
dc.identifier.trdizinid1218838
dc.identifier.urihttps://doi.org/10.29132/ijpas.1304265
dc.identifier.urihttps://hdl.handle.net/20.500.12885/4931
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofInternational Journal of Pure and Applied Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260207
dc.subjectGreen synthesis
dc.subjectProstate cancer
dc.subjectCopper oxide nanoparticle
dc.subjectPC3 prostate cell
dc.titleEffect of Copper Oxide Nanoparticles on Prostate Cancer PC3 Cells
dc.typeArticle

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