Yazar "Ulubayram, Neslihan" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Antifungal Activity of Bee Pollen Extracts Against Selected Filamentous Fungi
    (2025) Ulubayram, Neslihan; Cınar, Aycan Yıgıt
    Objective: Pollen is a natural bee product known for its rich bioactive content and positive effects on health. Although previous research has highlighted the antibacterial and antifungal properties of bee pollen, there is still a lack of comprehensive studies investigating its inhibitory effects on fungi, particularly molds. Our research seeks to contribute to filling this gap by assessing the antifungal potential of bee pollen against selected fungal species. Materials and methods: In this study, the antifungal properties of bee pollen obtained by combining two multifloral samples from the Bursa region were evaluated. Ethanolic and methanolic extracts of the bee pollen at varying concentrations (1%, 5%, 7.5%, and 10%) were tested for their inhibitory effects against Alternaria alternata, Penicillium chrysogenum, Fusarium culmorum, and Aspergillus flavus. Results and conclusion: Both pollen extracts exhibited dose-dependent antifungal activity against all tested fungal strains, with the methanol/water extract demonstrating significantly greater efficacy than the ethanol/water extract. The highest antifungal activity among all tested fungi was consistently observed at the 10% extract concentration. Among the tested strains, F. culmorum demonstrated the highest sensitivity, with a 7.5% concentration effectively inhibiting its growth. Given the promising antifungal potential, further investigation is needed to identify the primary bioactive compounds and elucidate their mechanisms of action.
  • Küçük Resim Yok
    Öğe
    Microencapsulated and Fresh Royal Jelly: Monitoring 10-HDA Content, Antibacterial and Antifungal Activity at Different Storage Periods
    (Inst Tecnologia Parana, 2023) Ulubayram, Neslihan; Cinar, Aycan Yigit
    Royal Jelly (RJ) is a unique functional food having rich nutrient composition. Due to its extremely sensitive and perishable nature, the cold chain is inevitable to maintain the biological properties of RJ. Microencapsulation is considered as an alternative technology for commercial RJ forms, owing to the elimination of cold-chain requirements. The objective of the study is to evaluate the microencapsulation of RJ and its protective effect on the 10-HDA content as well as on the antimicrobial activity during a defined storage period. Microcapsules were formed by utilizing alginate cross-linking technique in the encapsulator (Buchi B-390, Flawil, Switzerland) under 450 mbar. The antibacterial and antifungal activity of fresh and microencapsulated royal jelly (MRJ) was examined, comparatively. The possible changes in antimicrobial activity in the 1st, 3rd, and 6th months were evaluated considering the changes in 10-HDA levels. The antimicrobial efficiency of RJ on test bacteria (Micrococcus luteus, Staphylococcus epidermis, Salmonella Enteritidis, Escherichia coli) and yeast (Candida albicans, Candida parapsilosis) was maintained throughout the storage period. On the other hand, antifungal activity on test molds (Penicillium digitatum, Aspergillus flavus) slightly decreased from the 3rd month. No significant difference between 10-HDA contents was observed until the end of storage (p>0.05). The results indicate that microencapsulation retains the 10-HDA content of RJ for six months and is a promising method enabling storage at room temperature.
  • Küçük Resim Yok
    Öğe
    The role of microencapsulation in maintaining biological activity of royal jelly: comparison with biological activity and bioaccessibility of microencapsulated, fresh and lyophilized forms during storage
    (Wiley, 2022) Dundar, Ayse Neslihan; Cinar, Aycan; Altuntas, Seda; Ulubayram, Neslihan; Taner, Gokce; Dagdelen, Adnan Fatih; Oral, Rasim Alper
    BACKGROUND Royal jelly (RJ) is a unique beehive product and has been recommended for human health since ancient times because of its antioxidant, antimicrobial, antiproliferative, neuroprotective, anti-lipidemic and anti-aging features. However, the biggest obstacle in the use of RJ is the need for cold storage and the instability of bioactive components over time. In the present study, 10-hydroxy-2-decenoic acid (10-HDA) content, as well as antioxidant [using 1,1-diphenyl-2-picrylhydrazy and 2,2 '-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) methods] and antimicrobial activity (five Gram-positive, five Gram-negative and three yeasts), were comparatively evaluated for three RJ forms, two of which can be stored at 24 +/- 1 degrees C during storage. RESULTS Microencapsulated royal jelly (MRJ) stored at room temperature succeeded in preserving its 10-HDA content, a major bioactive compound, during the 6 months, with respect to lyophilized royal jelly (LRJ) and fresh RJ stored at 4 degrees C. The initial 10-HDA contents of RJ, LRJ and MRJ were determined as 1.90%, 5.26% and 2.75%, respectively. Moreover, the total phenolic content, antioxidant capacity and antimicrobial activity mostly remained constant throughout the storage period (P >= 0.05). Gram-positive strains were generally more sensitive than Gram-negative strains. In the present study, the in vitro simulated digestion analysis showed that MRJ can tolerate the digestion process. CONCLUSION Overall, the encapsulation process was considered as one preservative technique for RJ. The microencapsulation of RJ as shown in the results of the present study are encouraging in terms of enabling the local beekeeping sector to achieve ease of production and increased product diversity. MRJ shows promise as a commercial product with a high export value for producers. (c) 2022 Society of Chemical Industry.