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    Investigation of Swelling Capacity of Carboxymethyl Cellulose/Gelatin/Zinc Oxide Hydrogels
    (Hacettepe Üniversitesi, 2025) Arıkan, Ezgi; Kocabaş, Ecem Çiçek; Nuray, Batuhan; Efecan, Aleyna Tuğçe; Ciğeroğlu, Zeynep; Irmak, Emel Tamahkar
    Carboxymethyl cellulose (CMC)-based hydrogels had great potential in biomedical applications due to their biodegradability, biocompatibility, and solubility. Gelatin-based hydrogels were significant in the biomedical field for applications due to their high water retention capacity, biocompatibility, and biodegradability. Zinc oxide nanoparticles (ZnO) presenting high biocompatibility are widely used as an antimicrobial agent. CMC/Gelatin/ZnO hydrogels were developed with different ZnO nanoparticle ratios (0.05%, 0.1%) with further crosslinking using glutaraldehyde (1%, 2%, 2.5%, and 5%). The aim of this study was to investigate the effect of pH (pH: 5.5; 7.5) on the swelling behaviour of CMC/Gelatin/ZnO hydrogels. The increase in ZnO content resulted in the increase of swelling capacity. The highest swelling percentage (670%) occurred at pH 5.5 with the samples containing 0.1% ZnO. The lowest swelling ratio (467%) was observed at the pH 5.5 with the control group.
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    Polyvinylalcohol/Polyethyleneimine Hydrogels: Evaluation of Swelling, Dehydration and Antibacterial Activity
    (2024) Tamahkar, Emel; Özkahraman, Bengi; Bayrak, Gülşen; Perçin, Işık; Ciğeroğlu, Zeynep; Boran, Filiz
    In the present study, Polyvinylalcohol/polyethyleneimine (PVA/PEI) hydrogels designed with different Glutaraldehyde (Glu) amount, PEI amount and PVA concentration were synthesized via solvent casting technique. The fabricated PVA/PEI hydrogels with different compositions were evaluated for swelling rate, dehydration properties and antibacterial activity to determine superior combination. The swelling tests were performed for 0-300 min at pH 7.4 and 37 °C. All of the prepared PVA/PEI hydrogels swelling ratio were observed in the range of 221-321%. The highest dehydration rate was found for the PVA/PEI hydrogel with the lowest PVA concentration and the lowest dehydration rate was found for the PVA/PEI hydrogel with the highest Glu amount. All the PVA/PEI hydrogels demonstrated high antibacterial activity against E.coli. PP5 (prepared with 5% PVA, 0.5 mL PEI and 30 µL Glu) was determined as the selected hydrogels with optimized characteristics in respect to swelling, dehydration and antibacterial activity data. This study highlights potential usage of the resultant PVA/PEI hydrogels as antibacterial wound dressings in wound care applications.