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    Comparing the effectiveness of different vaccination regimens using Sinovac and BNT162b2 vaccines among hospitalised patients: A single-centre hospital-based retrospective cohort study
    (2025) Turan, Atakan; Öğüt, Hamdi; Varol, Aylin Ayyıldız; Koca, Nizameddin; Bozkurt, Hayri
    Objectives: This study aimed to assess the effectiveness of different vaccination regimens using two distinct SARS-CoV-2 vaccines against mortality risk and the need for intensive care unit (ICU) admission among hospitalised patients. Methods: The single-centre hospital-based retrospective cohort study was performed with adult COVID-19 patients in a tertiary-level hospital between March 2020 and September 2022. The associations between patients’ demographics and clinical features, vaccine status and regimens, in-hospital mortality, and need for ICU admission were evaluated using multivariable regression analyses. Results: During the study period, 2,373 patients were included. Mortality among unvaccinated patients was 85.0%, which was significantly lower in vaccinated groups (P<0.001), particularly with BNT162b2 than with Sinovac. Vaccination reduced mortality and ICU admission rates, with higher efficacy observed with increased vaccine doses and BNT162b2 regimens. Multivariable analyses confirmed age as a significant determinant and various vaccination schedules showed consistent reductions in mortality and ICU admissions. Conclusions: A two-dose initial plus one or more-dose booster BNT162b2 regimen effectively reduced mortality risks and ICU admission.
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    Comparison of changes in blood group, hemogram and biochemical parameters in healthcare workers with and without COVID-19
    (2025) Turan, Atakan; Öğüt, Hamdi; Bozkurt, Hayri; Varol, Aylin Ayyıldız
    Objective: This study aimed to evaluate blood groups and some hematologic and biochemical parameters in healthcare workers with and without COVID-19. Methods: The sample consisted of 1232 healthcare workers who consented to participate in the study after being informed about its purpose and methodology. The study's case group consisted of 704 individuals who got COVID-19, whereas the control group consisted of 528 individuals who didn't get the virus. A survey conducted online was used to gather data. The study was conducted with adherence to ethical norms. Results: Participants in the case and control groups showed a significant difference in their vitamin D level variables, and those with low vitamin D levels were 1.9 times more likely to contract COVID-19 than those with normal levels. Blood glucose, lactate dehydrogenase (LDH), ferritin, troponin-I, D-dimer, C-reactive protein (CRP), anti- human immunodeficiency virüs (HIV), white blood cell, hemoglobulin, platelets, lymphocyte, and neutrophil averages were significantly different between the case and control groups when the biochemistry values of the participants were compared (P<0.05). Conclusions: Vitamin D level, blood glucose, LDH, ferritin, troponin I, D-dimer, CRP, and anti-HIV among the significant biochemistry parameters in our study; leukocyte, hemoglobin, platelets, lymphocyte, and neutrophil levels among hemogram parameters are in parallel with the literature data in predicting the diagnosis of COVID-19. The use of these parameters in the clinic will contribute to the early detection of the diagnosis, early isolation of patients, and early initiation of the treatment process.