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    Characterizing the Mechanical Performance of a Bare-Metal Stent with an Auxetic Cell Geometry
    (Mdpi, 2022) Bhullar, Sukhwinder K.; Lekesiz, Huseyin; Karaca, Ahmet Abdullah; Cho, Yonghyun; Willerth, Stephanie Michelle; Jun, Martin B. G.
    This study develops and characterizes the distinctive mechanical features of a stainless-steel metal stent with a tailored structure. A high-precision femtosecond laser was used to micromachine a stent with re-entrant hexagonal (auxetic) cell geometry. We then characterized its mechanical behavior under various mechanical loadings using in vitro experiments and through finite element analysis. The stent properties, such as the higher capability of the stent to bear upon bending, exceptional advantage at elevated levels of twisting angles, and proper buckling, all ensured a preserved opening to maintain the blood flow. The outcomes of this preliminary study present a potential design for a stent with improved physiologically relevant mechanical conditions such as longitudinal contraction, radial strength, and migration of the stent.
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    Tailored-Biomaterials Based Potential Strategies for Cardiovascular Disease
    (Discovery Medicine, 2024) Bhullar, Sukhwinder K.; Mondal, Haimanti; Thomas, John; Ruzgar, Duygu Gazioglu; Chandrasekaran, Natarajan; Mukherjee, Amitava; Willerth, Stephanie M.
    Cardiovascular disease is a significant health concern worldwide, and varied effective treatment and prevention methods have been developed. Among these, tailored biomaterials-based strategies such as stents, scaffolds, patches, and drug delivery systems have emerged as a promising avenue. These devices are designed to match the mechanical and biological mechanisms of the cardiovascular system, ensuring optimal performance and compatibility. By effectively treating or preventing cardiovascular diseases, these devices have the potential to improve patient health outcomes significantly. They can restore blood flow by addressing blocked arteries and regenerate damaged cardiac tissue by delivering bioactive agents or cells directly to the affected area in a targeted, sustained, and controllable manner. Therefore, the objective of this article is to summarize the available evidence on these tailored biomaterial-based tunable cardiovascular devices. This knowledge can help to transform cardiovascular medicine for the treatment or prevention of cardiovascular disease and restore cardiac function to improve patients' quality of life.