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    Guanine oxidation signal enhancement in single strand DNA with polyacrylonitrile/polyaniline (PAN/PAni) hybrid nanofibers
    (Wiley, 2018) Cam, Ezginur; Tanik, Nilay Aladag; Çerkez, İdris; Demirkan, Elif; Aykut, Yakup
    Pure polyacrylonitrile (PAN) and polyacrylonitrile/polyaniline (PAN/PAni) hybrid nanofibers (NFs) were produced via electrospinning and used to monitor guanine oxidation in single strand DNA (ssDNA) by electrochemical methods. Two different methodologies were conducted. First, pre-synthesized PAni was added into electrospinning PAN solution and electrospun into composite PAN/PAni nanofibrous structure on cylindrical pencil graphite (PGE) surface. In the second route, PAN NFs were electrospun on a PGE surfaces and polymerization of PAni was conducted on the surfaces of the as-spun PAN NFs. NFs were kept at -18 degrees C in a refrigerator for several days. ssDNA was immobilized on the prepared NFs and guanine oxidation signals were observed for each system. The results revealed that use of PAN NFs enhanced signal intensity from 0.92 mu A (PGE) to 1.04 mu A (PAN NFs). Addition of PAni to PAN increased signal intensity to 1.23 mu A. When the PAN NF surfaces were coated with PAni, signal enhancement continued to increase up to 4.19 mu A for fourth day and decreased again when PAni-coated NFs were kept at -18 degrees C in the refrigerator. Since the prepared system is fast and cheap, it is promising for application in DNA biosensor devices. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45567.
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    PREPERATION AND ANTIBACTERIAL INVESTIGATION OF POLYCAPROLACTONE/CHITOSAN NANO/MICRO FIBERS BY USING DIFFERENT SOLVENT SYSTEMS
    (Ege Univ, 2018) Tursucular, Omer Firat; Çerkez, İdris; Orhan, Mehmet; Aykut, Yakup
    Chitosan (CHI) blended polycaprolactone (PCL) nano/micro fibers were prepared with different CHI content via electrospinning procedure. Two different solvents, acetone and formic acid (FA) were used to dissolve and blend the polymers before electrospinning process. Effect of the solvent on the electrospinability of the blend, final nano/micro fiber morphologies, chemical and thermal properties and antibacterial activities were investigated with SEM, FTIR, DSC, and ASTM 2149 01 Standard Dynamic Contact Conditions. The results revealed that chitosan particles were encapsulated in the as-spun PCL fibers with using acetone as the solvent resulted in reduced antibacterial activities Contrarily, when FA is used as the solvent, CHI and PCL were dissolved and blended very well, and enhanced antibacterial activities were obtained from as-spun PCL/CHI nano/micro fibers.