Sirin, ErsinSevimli, EsraSeyhan, GokceBarut, BurakKaya, YunusKoksoy, Baybars2026-02-082026-02-0820251300-0527https://doi.org/10.55730/1300-0527.3770https://hdl.handle.net/20.500.12885/6123Novel coumarin-triazole-coumarin dyads were synthesized and characterized, and their alpha-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC50value of 38.98 +/- 0.77 mu M. The IC50 values for 4d and 4a were 93.55 +/- 1.70 mu M and 95.04 +/- 3.55 mu M, respectively. The Lineweaver-Burk plot showed that 4e inhibited alpha-glycosidase in a mixed type. In addition, the Ki value obtained from the Dixon plot was 19.95 +/- 0.15 mu M for alpha-glycosidase.eninfo:eu-repo/semantics/openAccessCoumarintriazoleenzyme inhibitionalpha-glycosidaseArticle10.55730/1300-0527.3770496WOS:0016672198000082-s2.0-10502736844341510060Q3Q3