Enantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenes

Koz, GamzeKoz, ÖmerCoskun, Necdet2021-03-202021-03-2020160039-79111532-2432http://doi.org/10.1080/00397911.2016.1177728https://hdl.handle.net/20.500.12885/1114A series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu (II) catalytic system and moderate to good enantioselectivities (62-88%) and yields (66-96%) were obtained.eninfo:eu-repo/semantics/closedAccessAmino alcohol catalystenantioselective conjugate addition2-iminochromenenitromethaneEnantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenesArticle10.1080/00397911.2016.11777284610909915WOS:000378147800007Q3Q3