L-(+)-Tryptophan methyl ester derived polymeric microbeads as an efffiicient heterogeneous catalyst for green synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles

Poslu, Ayse HalicOsman, BilgenKaya, YunusKoz, OmerKoz, Gamze2026-02-122026-02-1220221300-0527https://doi.org/10.55730/1300-0527.3467https://search.trdizin.gov.tr/tr/yayin/detay/1142249https://hdl.handle.net/20.500.12885/6659The cross-linked microbeads with average diameter of 106-300 mu m, [poly(EGDMA-MATrp)], were obtained by copolymerization reaction of N-methacryloyl-L-(+)-tryptophan methyl ester (MATrp) with ethylene glycol dimethacrylate (EGDMA) and successfully applied as a heterogeneous catalyst in conjugate addition reaction of nitromethane to substituted 2-iminochromenes in aqueous media. A variety of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles has been synthesized in good yields. Polymeric microbeads were very durable and reused 5 times without a significant loss of activity. DFT calculations and experimental results revealed the significant role of Tr-Tr interactions as well as hydrogen bonding in the reaction mechanism.eninfo:eu-repo/semantics/openAccessPolymeric microbeadsL-(+)-tryptophan methyl esternitromethane additionTr-Tr interactionDFT calculationL-(+)-Tryptophan methyl ester derived polymeric microbeads as an efffiicient heterogeneous catalyst for green synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitrilesArticle10.55730/1300-0527.346746516421650WOS:0008763506000252-s2.0-85143168405Q4Q31142249