Koz, GamzeCoskun, Necdet2026-02-082026-02-0820232602-4217https://doi.org/10.38088/jise.1333127https://hdl.handle.net/20.500.12885/5020The organocatalyzed Morita-Baylis Hillman (MBH) reaction of ?-keto esters is a challenging carbon-carbon bond-forming reaction. We developed a catalytic system for the MBH reaction of methylphenyl glyoxylate with methyl vinyl ketone in a polar aprotic solvent. We used N-Boc-L-pipecolinic acid as a proton transfer mediator and 4-dimethylaminopyridine as the tertiary amine catalyst. We obtained the MBH adduct with a 66% yield in 48h. We proposed a detailed reaction mechanism involving a transition state that includes the hydrogen transfer by the acid functional group of N-Boc-L-pipecolinic acid.eninfo:eu-repo/semantics/openAccessMorita-Baylis Hillman reaction?-Keto esterN-Boc-L-pipecolinic acid4-DimethylaminopyridineArticle10.38088/jise.1333127721601661213613