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dc.contributor.authorBhullar, Sukhwinder Kaur
dc.contributor.authorGazioğlu Rüzgar, Duygu
dc.contributor.authorFortunato, Giuseppino
dc.contributor.authorAneja, Ginpreet Kaur
dc.contributor.authorOrhan, Mehmet
dc.contributor.authorSaber-Samandari, Saeed
dc.date.accessioned2021-03-20T20:12:27Z
dc.date.available2021-03-20T20:12:27Z
dc.date.issued2019
dc.identifier.issn1533-4880
dc.identifier.issn1533-4899
dc.identifier.urihttp://doi.org/10.1166/jnn.2019.16641
dc.identifier.urihttps://hdl.handle.net/20.500.12885/562
dc.descriptionWOS:000475752300010en_US
dc.descriptionPubMed ID: 31039846en_US
dc.description.abstractInfection is one of the major factors affecting wound healing. The use of polymeric fibrous constructs or scaffolds with encapsulated biologically active components has shown great potential in topical wound care as wound dressings to expedite wound healing process; however, there is a limitation in precise control over the release of active components. Therefore, in this study, the authors developed a facile method for controlled fabrication of poly(epsilon-caprolactone) (PCL) microfibrous constructs with silver (Ag) nanoparticles as antibacterial agent by single capillary electrospinning. By optimizing spinning parameters, the PCL microfibrous constructs were fabricated. The encapsulation of Ag nanoparticles within the PCL microfibers was confirmed using microstructural analysis. The encapsulation efficacy and release profile of Ag was evaluated in vitro. The diffusion study further revealed the controlled release and optimal bioavailability of Ag during the experimental period. In vitro assessment of antibacterial activity of electrospun hybrid constructs showed a high antibacterial activity and an inhibitory effect on the growth of both staphylococcus aureus and escherichia coli bacteria when compared to PCL and their efficiency of antibacterial activity also varied with respect to the percent of encapsulated Ag nanoparticles. This kind of Ag nanoparticles-loaded PCL microfibrous constructs may be considered for wound care applications.en_US
dc.language.isoengen_US
dc.publisherAmer Scientific Publishersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolymeric Constructen_US
dc.subjectSilver Nanoparticleen_US
dc.subjectElectrospinningen_US
dc.subjectAntimicrobialen_US
dc.subjectControlled Releaseen_US
dc.subjectWound Careen_US
dc.titleA Facile Method for Controlled Fabrication of Hybrid Silver Nanoparticle-Poly(epsilon-caprolactone) Fibrous Constructs with Antimicrobial Propertiesen_US
dc.typearticleen_US
dc.contributor.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Makine Mühendisliği Bölümüen_US
dc.contributor.institutionauthorBhullar, Sukhwinder Kaur
dc.identifier.doi10.1166/jnn.2019.16641
dc.identifier.volume19en_US
dc.identifier.issue11en_US
dc.identifier.startpage6949en_US
dc.identifier.endpage6955en_US
dc.relation.journalJournal Of Nanoscience And Nanotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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