Browsing by Author "Koz, Gamze"

DBU-catalyzed synthesis of novel 2-amino-3-nitrile-4H-chromenes

Koz, Gamze; Koz, Ömer (Walter De Gruyter Gmbh, 2017)

A simple method via the base-catalyzed Michael addition of nitroalkanes to 2-iminochromenes was developed, which leads to the production of highly functionalized 2-amino-3-nitrile-4H-chromenes in good yields.

Enantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenes

Koz, Gamze; Koz, Ömer; Coskun, Necdet (Taylor & Francis Inc, 2016)

A series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu ...

GC-MS Analysis of n-Hexane Extract of Saponaria prostrata WILLD. subsp. anatolica HEDGE

Koz, Gamze (2018)

The chemical constituents of n-hexane extract of S. prostrata WILLD. subsp. anatolica HEDGE which is an endemic species to Turkey was determined using GC-MS analysis. Twenty six components were identified with alpha-linolenic ...

GC-MS Analysis of N-Hexane Extracts of Turkish Ankyropetalum Species

Koz, Gamze; Koz, Ömer (2017)

The chemical constituents of crude n-hexane extracts of three Ankyropetalum species, Ankyropetalum gypsophiloides Fenzl, Ankyropetalum arsusianum Kotschy Ex Boiss. and Ankyropetalum reuteri Boiss. Et Hausskn. from Turkey ...

Regio- and diastereoselective synthesis of (E)-3-(2-aminochromen-4-yl)-6-aryl-substituted fulvenes

Koz, Gamze; Şahin, O.; Coşkun, N. (Verlag der Zeitschrift fur Naturforschung, 2016)

A practical base-catalyzed route was developed for the regio- and diastereoselective synthesis of (E)-3-aminochromene-6-aryl-disubstituted fulvenes in high yields up to 94% starting with the Michael addition of cyclopentadiene ...

Synthesis and Molecular Docking Studies of Novel 5-Arylideneaminouracils

Koz, Gamze (Maik Nauka/Interperiodica/Springer, 2019)

A series of novel 5-arylideneaminouracils is synthesized from 5-aminouracil and substituted salicylaldehydes, and characterized by spectroscopic methods. DNA interactions of model molecules are explored using molecular ...

Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule

Koz, Gamze (2018)

Anovel uracil derived compound, (E)-5-((3-chloro-2-hydroxybenzylidene)amino) pyrimidine-2,4(1H,3H)- dione, was synthesized and characterized using spectroscopic techniques. The interaction of the molecule with DNA was ...

Yeni ariliden urasil türevlerinin sentezi, yapı tayini ve sitotoksik aktivite çalışmaları

Halıç, Ayşe (Bursa Teknik Üniversitesi, 2021)

Günümüzde DNA, replikasyon ve transkripsiyon mekanizmalarındaki kritik rolü nedeniyle, antibiyotik, antikanser ve antiviral ilaçların geliştirilmesinde ana hedeflerden biri durumundadır. Kanser, aids, sıtma ve birçok ...